HERPES ZOSTER WITH MENINGITIS CAUSED BY TWO DIFFERENT VARICELLA VACCINE-ASSOCIATED VARICELLA-ZOSTER VIRUS STRAINS

Session ID:	S23
Author Name:	Myron J. Levin1, Roberta L. DeBiasi2, Vanda Bostik3, and D. Scott Schmid3 1 University of Colorado Health Sciences Center, University of Colorado Denver School of Medicine and Department of Pediatrics, Denver, CO 80262, 2 George Washington University Scho
Country:	US
Conference Session:	Session I

A previously healthy boy who had received varicella vaccine developed HZ with meningitis. The vaccine strain from skin lesions had the wild-type sequence polymorphism at position 108111, a vaccine marker never previously associated with adverse events. The CSF vaccine strain contained atypical transversion non-synonymous mutations at vaccine-associated SNPs in ORF54 and ORF59, also not previously observed. The presence of distinct strains in skin lesions and CSF indicate that more than one variant strain may reactivate to cause HZ.